ASTM E 1263 Standard Guide for Conduct of Micronucleus Assays in Mammalian Bone Marrow Erythrocytes
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ASTM E 1263 Document Information:
Title
Standard Guide for Conduct of Micronucleus Assays in Mammalian Bone Marrow Erythrocytes
ASTM International
Publication Date:
Mar 10, 1997
Scope:
This guide provides recommended guidelines for performing the
mammalian in vivo bone marrow micronucleus assay. Under
appropriate test conditions, measurement of the frequency of newly
formed micronucleated erythrocytes in bone marrow provides a
convenient index of chromosomal damage in nucleated erythrocyte
precursor cells. The rationale for the occurrence of micronuclei in
conjunction with chromosomal damage has been described previously
(1).2 This guide describes conditions under which the
frequency of micronucleated erythrocytes in mammalian bone marrow
is an appropriate measure of in vivo chromosomal damage, and
provides guidelines for the design and technical execution of
assays employing this endpoint.
The following guidelines for mammalian bone marrow erythrocyte
micronucleus assays have been published by organizations concerned
with the evaluation of genotoxicity test data. These references
should be consulted for recommendations on details not covered in
depth by this guide and for requirements of specific organizations
or government agencies (2-6).
The values stated in SI units are to be regarded as standard. No
other units of measurement are included in this standard.
This standard does not purport to address all of the safety
concerns, if any, associated with its use. It is the responsibility
of the user of this standard to establish appropriate safety and
health practices and determine the applicability of regulatory
limitations prior to use.
2 The boldface numbers in parentheses refer to the
list of references at the end of this guide.
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