ASTM F 2259 Standard Test Method for Determining the Chemical Composition and Sequence in Alginate by Proton Nuclear Magnetic Resonance (¹H NMR) Spectroscopy
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ASTM F 2259 Document Information:
Title
Standard Test Method for Determining the Chemical Composition and Sequence in Alginate by Proton Nuclear Magnetic Resonance (¹H NMR) Spectroscopy
ASTM International
Publication Date:
Apr 10, 2003
Scope:
This test method covers the determination of the composition and
monomer sequence of alginate
intended for use in biomedical and pharmaceutical applications as well
as in Tissue Engineered
Medical Products (TEMPs) by high-resolution proton NMR (¹H NMR).
A guide for the
characterization of alginate has been published as Guide F 2064.
Alginate, a linear polymer composed of ß-D-mannuronate (M) and its
C-5 epimer a-L-guluronate
(G) linked by ß-(1-->4) glycosidic bonds, is characterized by
calculating parameters such as
mannuronate/guluronate (M/G) ratio, guluronic acid content
(G-content), and average length of
blocks of consecutive G monomers (that is, NG>1). Knowledge of these
parameters is important for an
understanding of the functionality of alginate in TEMP formulations
and applications. This test
method will assist end users in choosing the correct alginate for
their particular application.
Alginate may have utility as a scaffold or matrix material for TEMPs,
in cell and tissue
encapsulation applications, and in drug delivery formulations.
This standard does not purport to address all of the safety concerns,
if any, associated with its
use. It is the responsibility of the user of this standard to
establish appropriate safety and
health practices and determine the applicability of regulatory
limitations prior to use.
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