ASTM E 1619 Standard Test Method for Chronic Oral Toxicity Study in Rats

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ASTM E 1619 Document Information:

Title
Standard Test Method for Chronic Oral Toxicity Study in Rats

ASTM International

Publication Date:
Jun 15, 1995

Scope:

This test method covers a long-term study to determine the effects of a substance in a mammalian species such as the rat following prolonged and repeated oral exposure. Under the conditions of the chronic toxicity test, effects that require a long latency period or that are cumulative should become manifest.

This test method assumes that the user is knowledgeable in mammalian toxicology and related pertinent areas, and relies heavily on the judgment of the evaluator.

The values stated in SI units are to be regarded as the standard. The inch-pound units given in parentheses are for information only.

This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use. For specific hazard statements, see Section 6.

Keywords:

blood chemistry
chronic toxicity
feed efficiency
gavage
hematology
LD50
necropsy
oral
pesticide
rat
toxicity
urinalysis

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