ASTM E 1242 Standard Practice for Using Octanol-Water Partition Coefficient to Estimate Median Lethal Concentrations for Fish Due to Narcosis
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ASTM E 1242 Document Information:
Title
Standard Practice for Using Octanol-Water Partition Coefficient to Estimate Median Lethal Concentrations for Fish Due to Narcosis
ASTM International
Publication Date:
Feb 10, 1997
Scope:
This practice covers a procedure for estimating the fathead
minnow (Pimephales promelas) 96-h LC50 of nonreactive
(that is, covalently bonded without unsaturated residues) and
nonelectrolytic (that is, require vigorous reagents to facilitate
substitution, addition, replacement reactions and are non-ionic,
non-dissociating in aqueous solutions) organic chemicals acting
solely by narcosis, also referred to as Meyer- Overton toxicity
relationship.2
This procedure is accurate for organic chemicals that are toxic
due to narcosis and are non-reactive and non-electrolytic. Examples
of appropriate chemicals are: alcohols, ketones, ethers, simple
halogenated aliphatics, aromatics, and aliphatic substituted
aromatics. It is not appropriate for chemicals whose structures
include a potential toxiphore (that structural component of a
chemical molecule that has been identified to show mammalian
toxicity, for example CN is known to be reponsible for inactivation
of enzymes, NO2 for decoupling of oxidative
phosphorylation, both leading to mammalian toxicity). Examples of
inappropriate chemicals are: carbamates, organophosphates, phenols,
beta-gamma unsaturated alcohols, electrophiles, and quaternary
ammonium salts.
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